Utilization of opioid analgesics for an prolonged time period all through pregnancy may result in neonatal opioid withdrawal syndrome [see WARNINGS AND PRECAUTIONS]. There are no readily available knowledge with DILAUDID INJECTION in pregnant Women of all ages to inform a drug-associated chance for significant beginning defects and miscarriage or adverse maternal outcomes.
Cure of Overdose In case of overdose, priorities are classified as the reestablishment of the patent airway and guarded airway and institution of assisted or managed air flow, if desired. Make use of other supportive actions (which include oxygen and vasopressors) while in the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require Superior daily life-assist techniques. The opioid antagonists, naloxone or nalmefene are specific antidotes to respiratory despair ensuing from opioid overdose. For clinically important respiratory or circulatory depression secondary to hydromorphone overdose, administer an opioid antagonist. Opioid antagonists really should not be administered during the absence of clinically major respiratory or circulatory melancholy secondary to hydromorphone overdose. As the length of opioid reversal is expected to generally be below the period of hydromorphone in DILAUDID INJECTION, carefully observe the client right up until spontaneous respiration is reliably reestablished.
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You'll want to deliver this record along with you each time you go to a physician or For anyone who is admitted to the hospital. Additionally it is critical facts to carry with you in case of emergencies.
Opioid antagonists shouldn't be administered while in the absence of clinically considerable respiratory or circulatory depression secondary to hydromorphone overdose.
Opioids may additionally obscure the scientific class inside a affected person that has a head injuries. Prevent the usage of DILAUDID INJECTION in sufferers with impaired consciousness or coma.
Hydromorphone wasn't mutagenic within the in vitro bacterial reverse mutation assay (Ames assay). Hydromorphone was not clastogenic in possibly the in vitro human lymphocyte chromosome aberration assay or maybe the in vivo mouse micronucleus assay.
Hydromorphone brings about a reduction in motility linked to an increase in smooth muscle mass tone in the antrum of the tummy and duodenum. Digestion of food in the little intestine is delayed and propulsive contractions are lessened.
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Check individuals for indications of urinary retention or minimized gastric motility when DILAUDID INJECTION is utilised concomitantly with anticholinergic medicines.
abnormal vision, like modifications in color vision (for example getting a blue coloration tinge) and blurred eyesight
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Hydromorphone injection might result in other Unwanted effects. Simply call your health care provider When you've got any abnormal problems while you're making use of this medication.
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